http://rdf.ncbi.nlm.nih.gov/pubchem/patent/ES-2241194-T3
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_4dac022280ec96f54c694eb427655932 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D471-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D403-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D401-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D401-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D209-42 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P7-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P9-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P43-00 |
| classificationIPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D209-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D221-00 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D471-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D209-42 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D401-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D401-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-403 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-40 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-404 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-4375 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-4427 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D403-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-4439 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-4178 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P7-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P9-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-454 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-4725 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-4709 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-475 |
| filingDate | 1998-12-10-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2005-10-16-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_e723b63a82824316ab90e8283bc74193 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_818d31a71e0334e8109af76eca1f365f http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_e0d6ea0a4cddfe39872b72f0070687b8 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_89a15bdcdffb94f49b08e5b1f30b0c16 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_0348d7ce54c72e5521512299ead6c056 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_40dc5a911cc2e8473429df5dcbc6c4d6 |
| publicationDate | 2005-10-16-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | ES-2241194-T3 |
| titleOfInvention | INDOL DERIVATIVES IN QUALITY OF FACTOR XA INHIBITORS. |
| abstract | A compound of the formula I, ** (Formula) ** in which: two of the residues R1a, R1b, R1c and R1d independently of each other are hydrogen, F, Cl, Br, I, methyl, (C1-) alkoxy C4), phenyl (C1-C4) alkoxy -, OH or NR5aR5b, and are identical or different, and the other two of the moieties R1a, R1b, R1c and R1d are hydrogen; R5a is hydrogen or ((C1-C4) alkoxy) carbonyl-; R5b is hydrogen; R2 is hydrogen, Cl or Br; R3 is -CO-NHR10; R7 is hydroxy, (C1-C4) alkoxy, phenyl (C1-C4) alkoxy - or -NR5aR5b; R10 is (C1-C10) alkyl -, phenyl-(C1-C4) alkyl - or naphthyl-(C1-C4) alkyl -, where the (C1-C4) alkyl moiety -, the phenyl moiety and the naphthyl moiety are not substituted or substituted with one, two or three identical or different R11 moieties; R11 is -N (R12) 2, -OR12, -CO-N (R13) 2, -CO-R7, R15b, (C1-C14) alkyl, phenyl that is unsubstituted or substituted with one, two or three moieties Identical or different R15b, naphthyl that is unsubstituted or substituted with one, two or three identical or different R15b moieties, quinolinyl that is unsubstituted or substituted with one, two or three identical or different R15b moieties and / or substituted therein nitrogen atom with R14, isoquinolinyl that is unsubstituted or substituted with one, two or three identical or different R15b moieties and / or substituted on the nitrogen atom with R14, pyridyl that is unsubstituted or substituted on the nitrogen atom with R14, or Het that is not substituted or substituted with R15a, where the R11 residues, if they appear more than once in the molecule, are independent of each other and may be identical or different; Het is the remainder of a saturated heterocyclic ring of 5 or 6 atoms containing 1 or 2 identical or different ring heteroatoms that are selected from the series consisting of nitrogen, oxygen and sulfur; each R12 moiety, regardless of the denotation of another R12 moiety, is hydrogen, (C1-C4) alkyl, phenyl, phenyl (C1-C4) alkyl -, naphthyl, naphthyl (C1-C4) alkyl -, pyrrolidinyl, piperidinyl, pyrrolidinyl - (C1-C4) alkyl -o piperidinyl-(C1-C4) alkyl -, where each pyrrolidinyl moiety and each piperidinyl moiety is not substituted or is substituted on the nitrogen atom with phenyl-C1-C4 alkyl - or R15a; each R13 moiety, regardless of the denotation of another R13 moiety, is hydrogen, (C1-C4) alkyl, phenyl, phenylalkyl (C1-C4) -, naphthyl or naphthyl (C1-C4) alkyl -, or the two R13 moieties together with the nitrogen atom to which they are attached they form a saturated heterocyclic ring of 5 or 6 atoms that may contain an additional nitrogen atom or oxygen atom in the ring where the additional nitrogen atom in the ring is not substituted or is substituted with (C1-C4) alkyl or phenyl (C1-C4) alkyl; R14 is (C1-C6) alkyl, (C1-C6) alkenyl, (C1-C6) alkynyl, phenyl (C1-C6) alkyl - or ((C1-C6) alkoxy) carbonyl (C1-C6) alkyl - , where the phenyl present in R14 denotes an unsubstituted phenyl moiety, the substitution with these moieties in the nitrogen atom of the heterocyclic moiety leads to a positively charged group having X- as a complementary ion; or R14 is oxide, this substitution in the nitrogen atom of the heterocyclic moiety leads to an N oxide; and where the R14 moieties, if they appear more than once in the molecule, are independent of each other and may be identical or different; R15a is (C1-C6) alkyl, ((C1-C6) alkyl) - C (= NH) -, - (CH2) tN (R16) 2, - (CH2) t-N + (R16a) 2 (-O- ), (CH 2) tN + (Ri6a) 3X (CH2) t-N + (R16a) 3X-, - (CH2) t-NHR17, - (CH2) t-CN, - (CH2) t-CS-N ( R18) 2, - (CH2) tC (= NR17) -NHR17 or - (CH2) t-NH-C (= NR17) -NHR17. |
| priorityDate | 1997-12-24-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 622.