| abstract |
A compound having the Formula or a pharmaceutically acceptable salt thereof, wherein; B is selected from the group consisting of: (i) aryl and heteroaryl in which one carbon adjacent to the carbon at the junction point is optionally substituted by R32, the other carbon adjacent to the carbon at the junction point is optionally substituted by R36 , a carbon adjacent to R32 and two atoms from the carbon at the point of attachment is optionally substituted by R33, a carbon adjacent to R36 and two atoms from the carbon at the point of attachment is optionally substituted by R35 and any carbon adjacent to both R33 as R35 is optionally substituted by R34; (ii) hydride, alkyl of 2 to 8 carbon atoms, alkenyl of 3 to 8 carbon atoms, alkynyl of 3 to 8 carbon atoms and haloalkyl of 2 to 8 carbon atoms, in which each member of group B is optionally substituted on any carbon up to and including 6 atoms from the point of attachment of B to A with one or more of the group consisting of R32, R33, R34, R35 and R36; and (iii) cycloalkyl of 3 to 7 carbon atoms and saturated heterocyclyl of 4 to 6 carbon atoms, wherein each ring carbon is optionally substituted with R33, a ring carbon other than the ring carbon at the point of attachment B to A is optionally substituted with oxo provided that no more than one ring carbon is substituted by oxo at the same time, ring carbons and a nitrogen adjacent to the carbon atom at the junction point are optionally substituted with R9 or R13, a ring or nitrogen carbon adjacent to position R9 and two atoms from the point of attachment is optionally substituted with R10, a ring or nitrogen carbon adjacent to position R13 and two atoms from the point of attachment is optionally substituted with R12 |