| abstract |
Compound of formula (I): ** (Formula) ** in which: Z1 is CR1, Z2 is CR2, Z3 is CR3, and Z4 is CR4; W1 is NR5, W2 is N, and W3 is CG; or W1 is NG, W2 is N, and W3 is CR6; G has the formula (II): ** (Formula) ** Y is O, S, CHOH, -NHC (O) -, -C (O) -, -NR7-, -CH = N-, or absent; p is 1, 2, 3, 4 or 5; Z is CR8R9 or absent; each t is 1, 2 or 3; each R1, R2, R3, and R4, independently, is H, amino, hydroxyl, halo, or C1-6 straight or branched chain alkyl, C2-6 alkenyl, C2-6 alkynyl, C1-6 alkyl with 1 or 2 heteroatoms selected from O, S and N, C1-6 haloalkyl, -CN, -CF3, -OR11, -COR11, -NO2, -SR11, -NHC (O) R11, -C (O) NR12R13, -NR12R13, - NR11C (O) NR12R13, -SO2NR12R13, -OC (O) R11, -O (CH2) qNR12R13, or - (CH2) qNR12R13, where q is an integer between 2 and 6; each R5, R6, and R7, independently, is H, C1-6 alkyl; formyl; C3-6 cycloalkyl; each R8 and R9, independently, is H or C1-8 straight or branched chain alkyl; R10 is straight or branched C1-8 alkyl, C2-8 alkenyl, C2-8 alkynyl, C1-8 alkylidene, C1-8 alkoxide, C1-8 alkyl with 1 or 2 heteroatoms selected from O, S and N, aminoalkyl C1-8, C1-8 haloalkyl, C1-8 alkoxycarbonyl, C1-8 hydroxyalkoxide, C1-8 hydroxyalkyl, -SH, C1-8 alkylthio, aryl -O-CH2-C5-6, C5-6 cycloalkyl, -C ( O) -NR12R13, -NR11C (O) NR12R13, -CR11R12R13, -OC (O) R11, -O (CH2) SNR12R13, or - (CH2) SNR12R13, in which S is an integer between 2 and 8; R10 is H, C1-8 straight or branched chain alkyl, C2-8 alkenyl, C2-8 alkynyl, C1-8 alkylidene, C1-8 alkoxide, C1-8 alkyl with 1 or 2 heteroatoms selected from O, S and N, C 1-8 aminoalkyl, C 1-8 haloalkyl, C 1-8 alkoxycarbonyl, C 1-8 hydroxyalkoxide, C 1-8 hydroxyalkyl, or C 1-8 alkylthio; each R11, independently, is H, C1-8 straight or branched chain alkyl, C2-8 alkenyl, C2-8 alkynyl, C2-8 alkyl with 1 or 2 heteroatoms selected from O, S and N, C2-8 aminoalkyl, C2-8 haloalkyl, C1,8 alkoxycarbonyl, C2-8 hydroxyalkyl, aryl -C (O) -C5-6 substituted with C1-3 alkyl or halo, C5-6 aryl, C5-6 heteroaryl, C5-6 cycloalkyl, heterocycloalkyl C5-6, -C (O) -NR12R13, -CR5R12R13, - (CH2) tNR12R13, in which t is an integer between 2 and 8; and each R12 and R13, independently, is H, C1-6 alkyl; C3-6 cycloalkyl; or C5-6 heteroaryl, optionally substituted with halo or C1-6 alkyl; or R12 and R13 together form a cyclic structure; or a pharmaceutically acceptable salt or ester thereof. |