| abstract |
A compound of Formula I ** (Formula) ** or a pharmaceutically acceptable salt or stereoisomer thereof, wherein: Z is: ** (Formula) ** a is 0 or 1; b is 0 or 1; m is 0, 1 or 2; s is 1 or 2; t is 1, 2 or 3; R1 and R5 are independently selected from: 1) H, 2) (C = O) to C1-C10 alkyl, 3) (C = O) to Obaryl, 4) (C = O) to C2-C10 Obalkenyl, 5) ( C = O) a C2-C10 Obalquinyl, 6) CO2H, 7) halo, 8) OH, 9) C1-C6 obperfluoroalkyl, 10) (C = O) aNR7R8, 11) CN, 12) (C = O) a C3-C8 cycloalkyl, and 13) (C = O) aObheterocyclyl. |