http://rdf.ncbi.nlm.nih.gov/pubchem/patent/ES-2234447-A1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_b070d762ee824c320f719e5666f35ee8 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D281-16 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D295-18 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D281-16 |
| filingDate | 2005-03-07-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_8b30a4688379c9d135cce2b855e3814d http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_e8ac75ba37410e1e9554c5ba32ec3389 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_65d12dca4feac804b17be273d46631af http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_1a77eff94ef6092f07bb05fad1dd04e0 |
| publicationDate | 2005-06-16-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | ES-2234447-A1 |
| titleOfInvention | PROCEDURE FOR OBTAINING A DERIVATIVE OF 11- (4-SUBSTITUTED-1-PIPERAZINIL) DIBENZO (B, F) (1,4) TIAZEPIN. |
| abstract | Procedure for obtaining a derivative of 11- (4-substituted-1-piperazinyl) dibenzo [ b, f ] [1,4] thiazepine.n n n Procedure for obtaining a derivative of 11- (4-substituted-1-piperazinyl) dibenzo [ b, f ] [1,4] thiazepine. The process for obtaining a derivative of 11- (4-substituted-1-piperazinyl) dibenzo [ b, f ] [1,4] thiazepine, of general formula I, wherein A means hydrogen or a group - (CH 2) 2 -OH or a group - (CH 2) 2 -O- (CH 2) 2 -OH, or a salt thereof, it comprises a step in which 10H-dibenzo- [ b, f ] [1,4] thiazepin-11-one is reacted with a piperazine derivative, in the presence of a titanium alkoxide, of the general formula Ti (OR) 4, where R is a linear or branched alkyl group of one to eight carbon atoms, to obtain said derivative of formula I or a salt thereof. In the event that A is - (CH 2) 2 -O- (CH 2) 2 -OH, then the piperazine derivative is 1- (2- (2-hydroxyethoxy) ethyl ) piperazine and the derivative of 11- (4-substituted-1-piperazinyl) dibenzo [ b, f ] [1,4] thiazepine is quetiapine (11- (4- (2- (2-hydroxyethoxy) ethyl) -1- piperazinyl) dibenzo [ b, f ] [1,4] thiazepine). The process may comprise an additional step of reacting quetiapine with fumaric acid to obtain quetiapine hemifumarate.n n n n one |
| priorityDate | 2005-03-07-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 83.