| abstract |
Compounds of the general formula wherein R is hydrogen, C1-C7 alkyl, C1-C7 alkoxy, halogen, amino, -N (R6) 2 or trifluoromethyl; R1 is hydrogen, C1-C7 alkoxy or halogen; R and R1 can be together -CH = CH-CH = CH-; R2 is halogen, C1-C7 alkyl or trifluoromethyl; R3 is hydrogen or C1-C7 alkyl; R4 is hydrogen or a cyclic tertiary amine, optionally substituted by C1-C7 alkyl; R5 is hydrogen, nitro, amino or ¿N (R6) 2; R6 is hydrogen or C1-C7 alkyl; X is ¿C (O) N (R6) -, - (CH2) nO-, - (CH2) nN (R6) -, -N (R6) C (O) - or ¿N (R6) (CH2) n -; and n is 1-2; and salts derived from a pharmaceutically acceptable acid addition, with the exclusion of the compounds [1,1,1-biphenyl] -2-methanamine, N- [1,4-methylphenyl) methyl] and [1,1,1-biphenyl] - 2-methanamine, N - [[4- (1,1-dimethylethyl) phenyl] methyl] -N-methyl hydrochloride. |