| abstract |
A compound of the ** formula ** racemic-diastereomeric mixtures and optical isomers of said compound of formula (I), or a pharmaceutically acceptable salt thereof R1 is H, - (CH2) mC (O) - (CH2) m- Z1, - (CH2) m-Z1, - (CH2) mO-Z1 or - (C0-C6) alkyl-C (O) -NH (CH2) m-Z3; Z1 is an optionally substituted fraction selected from the group consisting of (C1-C12) alkyl, benzo [b] thiophene, phenyl, naphthyl, benzo [b] furanyl, thiophene, isoxazolyl, indolyl R2 is H or (C1-C6) alkyl; or R1 and R2 are taken together with the nitrogen atoms to which they are attached to form a compound of formula (Ia), (Ib) or (Ic), R3 is - (CH2) m-E- (CH2) m-Z2; E is O, S, -C (O) -, -C (O) -O, -NH-C (O) -O or a bond; Z2 is (C1-C12) alkyl, amino, (C1-C12) alkylamino, N, N-di- (C1-C12) alkylamino, (C1-C12) alkylguanidino or an optionally substituted fraction selected from the group consisting of phenyl, indolyl , imidazolyl, thiophene, benzothiophene, pyridinyl and naphthyl; R4 is H or - (CH2) m-A1; A1 is -C (= Y) -n (X1X2), -C (= Y) -X2, -C (= NH) -X2 or X2. |