| abstract |
The invention relates to new derivatives of aromatic rings represented by formula (I) or their pharmaceutically acceptable salts, in which Nu represents an aromatic ring of 5 or 6 elements; ch {sub, 1} and ch {sub, 2} each represents a cross-linking group and A represents an aromatic ring. These compounds have activity to lower blood sugar or PDE 5 inhibitory activity and are useful as medications to treat decreased glucose tolerance, diabetes, diabetic complications, insulin resistance syndrome, polycystic ovary syndrome, hyperlipidemia, arteriosclerosis , cardiovascular disorders, hyperglycemia, hypertension, stenocardia, pulmonary hypertension, congestive heart attack, glomerulopathy, tubulointestinal disorders, renal failure, angiostenosis, distal angiopathy, stroke, chronic reversible obstruction, autoimmune diseases, allergic rhinitis, urticaria, glaucoma, diseases characterized by disorders of enteromotility, impotence, nephritis, cachexia, pancreatitis restenosis after PTCA, etc. |