http://rdf.ncbi.nlm.nih.gov/pubchem/patent/ES-2228824-T3
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_1bde28565d28f037e78bf4a67776ee24 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-24 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D307-87 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D307-87 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07B61-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P25-24 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/H01L21-00 |
| filingDate | 2001-03-07-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2005-04-16-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_bcdefeccbb19703e609c591b5f35f7d9 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_fab9bd5f2956a73ab96a12ae41662b6c http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_c75f07838a8a23c74523afb6436a2ab3 |
| publicationDate | 2005-04-16-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | ES-2228824-T3 |
| titleOfInvention | PURE CITALOPRAM PREPARATION METHOD. |
| abstract | A process for preparing citalopram ** (Formula) ** in which a compound of formula II ** (Formula) ** in which Z is iodine, bromine, chlorine or CF3- (CF2) n-SO2-O-, where n 0, 1, 2, 3, 4, 5, 6, 7 or 8, is subjected to a cyanide exchange reaction with a cyanide source; The resulting crude citalopram product is optionally subjected to initial purification and then treated with an amide group forming agent or similar to amide chosen from the agents of Formulas (a), (b) or (c): ** ( Formulas) ** where X is halogen or an O-CO-R ¿group, Hal is halogen, Y is O or S, W is O, N or S and R, R¿, R¿ and R¿ are chosen each independently from the group consisting of hydrogen, alkyl and aryl or optionally substituted aralkyl; The reaction mixture is then subjected to an acid / base wash and / or crystallization and recrystallization of citalopram in order to remove the amides formed from the crude citalopram mixture; and the resulting citalopram product is optionally purified more intensely, and is then processed and isolated as a base or as a pharmaceutically acceptable salt thereof. |
| priorityDate | 2000-12-22-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 56.