http://rdf.ncbi.nlm.nih.gov/pubchem/patent/ES-2226297-T3
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_c76ecadad74a1a35270b3e3a34d60f37 |
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/Y02P20-55 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D487-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D247-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P43-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P5-06 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D487-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D247-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P5-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P43-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K5-062 |
| filingDate | 1999-11-18-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2005-03-16-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_12d3610f69f32de6f80a3b8e2b8c57f4 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_23c2566c2061e2b83473e8ff20651721 |
| publicationDate | 2005-03-16-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | ES-2226297-T3 |
| titleOfInvention | HYDANTOINE PROCEDURES AND INTERMEDIARIES FOR THE SYNTHESIS OF SECRETAGOGOS OF GROWTH HORMONE. |
| abstract | A process for preparing a compound of Formula I ** (Formula) ** in which R1 is - (CH2) qN (X6) C (O) X6, - (CH2) qN (X6) C (O) (CH2) t-A1, - (CH2) qN (X6) S (O) 2 (CH2) t-A1, - (CH2) qN (X6) S (O) 2X6, (CH2) qN (X6) C (O) N (X6) (CH2) t-A1, - (CH2) qN (X6) C (O) N (X6) (X6), - (CH2) qC (O) N (X6) (X6), - (CH2) qC (O) N (X6) (CH2) tA1, - (CH2) qC (O) OX6, - (CH2) qC (O) O (CH2) t-A1, - (CH2) qOX6, - (CH2) qOC (O) X6, - (CH2) qOC (O) (CH2) t-A1, - (CH2) qOC (O) N (X6) (CH2) t-A1, - (CH2) qOC (O) N (X6 ) (X6), - (CH2) qC (O) X6, - (CH2) qC (O) (CH2) t-A1, - (CH2) qN (X6) C (O) OX6, - (CH2) qN ( X6) S (O) 2N (X6) (X6), - (CH2) qS (O) mX6, - (CH2) qS (O) m (CH2) t-A1, -alkyl (C1-C10), - ( CH2) q-A1, - (CH2) q-cycloalkyl (C3-C7), - (CH2) q-Y1-alkyl (C1-C6), - (CH2) q-Y1- (CH2) t-A1 or - (CH2) q-Y1- (CH2) t-cycloalkyl (C3-C7); wherein in the definition of R1 the alkyl and cycloalkyl groups are optionally substituted with (C1C4) alkyl, hydroxy, (C1-C4) alkoxy, carboxyl, -CONH2, -S (O) (C1-C6) alkyl, ester of -CO2 (C1-C4) alkyl, 1H-tetrazol-5-yl or 1, 2 or 3 fluoro groups; Y1 is O, S (O) m, -C (O) NX6-, -CH = CH-, = -C ~ C-. -N (X6) C (O) -, -C (O) NX6-, -C (O) O-, OC (O) N (X6) -0 OC (O); q is 1, 2, 3 or 4; t is 0, 1, 2 or 3; said group (CH2) q and group (CH2) t in the definition of R1 are optionally independently substituted with hydroxy, (C1-C4) alkoxy, carboxyl, -CONH2, -S (O) (C1-C6) alkyl, ester of -CO2 (C1-C4) alkyl, 1H-tetrazol-5-yl, 1, 2 or 3 fluoro groups or 1 or 2 (C1-C4) alkyl groups; and R2 is hydrogen, (C1-C8) alkyl, - (C0-C3) alkyl - (C3-C8) cycloalkyl, - (C1-C4) alkyl-A1 or A1; where the alkyl groups and cycloalkyl groups in the definition of R1 are optionally substituted with hydroxy, -C (O) OX6, -C (O) N (X6) (X6), -N (X6) (X6), -S (O) (C1-C6), -C (O) A1, -C (O) (X6), CF3, CN or 1, 2 or 3 independently selected halo groups; A1 is independently selected when it is present from the group consisting of cycloalkenyl (C5-C7), phenyl, a partially saturated 4 to 8-membered ring, completely saturated or completely unsaturated, optionally with 1 to 4 heteroatoms independently selected from the group consisting of oxygen, sulfur and nitrogen and a bicyclic ring system consisting of a partially saturated or partially saturated 5 or 6-membered ring, completely unsaturated or fully saturated, optionally with 1 to 4 heteroatoms independently selected from the group consisting of nitrogen, sulfur and oxygen, condensed into a ring of 5 or 6 members partially saturated, completely saturated or completely unsaturated, optionally with 1 to 4 heteroatoms independently selected from the group consisting of nitrogen, sulfur and oxygen; A1 when present is optionally independently substituted, in one or both rings optionally if A1 is a bicyclic ring system, with up to three substituents, each substituent independently selected from the group consisting of F, CI, Br, I, OCF3 , OCF2H, CF3, CH3, OCH3, -OX6, -C (O) N (X6) (X6), -C (O) OX6, oxo, (C1-C6) alkyl, nitro, cyano, benzyl, -S ( O) (C1-C6), 1H-tetrazol-5-yl, phenyl, phenoxy, phenylalkyl, halophenyl, methylenedioxy, -N (X6) (X6), -N (X6) C (O) X6), -S (O) 2N (X6) (X6), -N (X6) S (O) 2-phenyl, -N (X6) S (O) 2X6, -CONX11X12, -S (O) 2NX11X12, -NX6S (O) 2X12, -NX6CONX11X12, -NX6S (O) 2NX11X12, -NX6C (O) X12, imidazolyl, thiazolyl and tetrazolyl, so that if A1 is optionally substituted with methylenedioxy then it can only be substituted with a methylenedioxy. |
| priorityDate | 1998-11-23-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
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