| abstract |
New 4,5-diaryl 2-substituted imidazoles are presented in which: i) the nitrogen atom in position 1 is substituted by a substituent containing trialkylsilyl or ii) the substituent in position 2 is arylalkyl, arylsulfonyl, arylthio, arylselene, arylteluro, cycloalkyl, cycloalkenyl, alkylcycloalkyl, alkylcycloalkenyl, amino or hydrazino or N-heterocyclyl in which the ring containing N has 6 members, in particular compounds of the formula (I) in which R {sub, 1 are supplied }, R {sub, 2}, R {sub, 3} and R {sub, 4} are as defined, in free form or pharmacologically acceptable acid addition salt or physiologically divisible ester, which have inhibitory activity of mitogen activated by protein kinase p38. The compounds are used as pharmaceuticals for the treatment of diseases associated with TNF {al} and IL-1 such as rheumatoid arthritis and bone metabolism diseases, for example osteoporosis. |