| abstract |
A halogen substituted 4-phenyl-1-piperazinyl derivative of formula I: ** (Formula) ** in which W is C, CH or N and the dotted line leaving W indicates a bond when W is C and there is no link when W is N or CH; R1 and R2 are independently selected from hydrogen and halogen, provided that at least one of R1 and R2 is a halogen atom; R3 is selected from: hydrogen, halogen, C1-6 alkyl, CC2-6 alkenyl, C2-6 alkynyl, trifluoromethyl, C1-6 alkoxy, aryloxy, aralkoxy, hydroxy, amino, C1-6 alkylamino, di (C1-6 alkyl ) amino, nitro and cyano, n is 2, 3, 4 or 5; X is CH2, CO, CS, SO or SO2; and Q is an optionally substituted 1-indolinyl group of the formula: ** (Formula) ** in which R4, R5, R6, R7, R8 and R9 are independently selected from: hydrogen, halogen, trifluoromethyl, nitro, cyano, alkyl C 1-6, C 2-6 alkenyl, C 2-6 alkynyl, C 1-6 alkoxy, C 1-6 alkylthio, C 1-6 alkylsulfonyl, hydroxy, C 1-6 hydroxyalkyl, amino, C 1-6 alkylamino, di (C 1-6 alkyl) amino, acyl, aminocarbonyl, C16 alkylaminocarbonyl and di (C1-6 alkyl) aminocarbonyl; and any of its enantiomers and acid addition salts thereof. |