| abstract |
Procedure for the production of cyclic pentapeptide cyclo- (Arg-Gly-Asp-DPhe-NMeVal) by cyclization of a linear pentapeptide, selected from the group H-Arg (Pbf) -Gly-Asp (OBzl) -DPhe-NMeVal-OH, H-Gly-Asp (OBzl) -DPhe-NMeVal-Arg (Pbf) -OH, H-Asp (OBzl) -DPhe-NMeVal-Arg (Pbf) -Gly-OH, H-DPhe-NMeVal-Arg (Pbf) -Gly-Asp (OBzl) -OH or H-NMeVal-Arg (Pbf) -Gly-Asp (OBzl) -DPhe-OH, subsequent dissociation of the protective groups and, optionally, additional transformation into their physiologically harmless salts. |