| abstract |
Compound having the ** formula ** in which R1-R5 are independently selected from hydrogen, alkyl of 1 to 6 carbon atoms, alkenyl of 2 to 6 carbon atoms, alkynyl of 2 to 6 carbon atoms, perhaloalkyl of 1 to 6 carbon atoms, cycloalkyl of 3 to 10 carbon atoms, heterocycloalkyl of 3 to 10 members, aryl, heteroaryl, halogen, -CN, -NO2, -CO2R6, -COR6, -OR6, -SR6, - SOR6, -SO2R6, -CONR7R8, -NR6N (R7R8), -N (R7R8) or -WY- (CH2) nZ, with the proviso that at least one of R1-R5 is not hydrogen; or R2 and R3 or R3 and R4, together form a 3-7 membered heterocycloalkyl or 3-7 membered heteroaryl; R6 and R7 are, independently, hydrogen, alkyl of 1 to 6 carbon atoms, perhaloalkyl of 1 to 6 carbon atoms, or aryl; R8 is hydrogen, alkyl of 1 to 6 carbon atoms, perhaloalkyl of 1 to 6 carbon atoms, cycloalkyl of 3 to 10 carbon atoms, heterocycloalkyl of 3 to 10 members, aryl or heteroaryl, or R7 and R8, can together form a 3- to 7-membered heterocycloalkyl; W is O, NR6, or is absent; And it is - (CO) - or - (CO2) -, or is absent; Z is alkyl of 1 to 4 carbon atoms, -CN, -CO2R6, - COR6, -CONR7R8, -OCOR6, -NR6COR7, -OR6, -SR6, - SOR6, -SO2R6, -N (R7R8) or phenyl; G is phenyl optionally substituted with one or more substituents selected from alkyl of 1 to 6 carbon atoms, alkenyl of 2 to 6 carbon atoms, alkynyl of 2 to 6 carbon atoms, perhaloalkyl of 1 to 6 carbon atoms, 3 to 10 carbon cycloalkyl, 3 to 10 membered heterocycloalkyl, aryl, heteroaryl, halogen, -CN, -NO2, -CO2R6, -COR6, -OR6, -SR6, -SOR6, -SO2R6, - CONR7R8, - NR6N (R7R8), -N (R7R8) or -WY- (CH2) nZ; or G is quinolyl, isoquinolyl or benzofuranyl; or a pharmaceutical salt thereof. |