| abstract |
A compound of ** formula ** in which R is - (CH2) nX, where n is 1, 2 or 3 and X is alkyl of 1 to 4 carbon atoms, alkoxy of 1 to 4 carbon atoms, alkenyl from 2 to 7 carbon atoms, alkynyl of 2 to 7 carbon atoms, carboxy, alkoxy (from 1 to 4 carbon atoms) -carbonyl, cyano, tetrazolyl, cycloalkyl (from 3 to 7 carbon atoms) -amino or imidazolyl -alkyl (from 1 to 4 carbon atoms) -amino, or R is -CH2CON (R1) R2, where R1 and R2, independently, are hydrogen, hydroxy, alkyl of 1 to 4 carbon atoms, benzyl, di- alkyl (from 1 to 4 carbon atoms) -amino-alkyl (from 1 to 4 carbon atoms), alkenyl of 2 to 7 carbon atoms, alkynyl of 2 to 7 carbon atoms, hydroxy-alkyl (from 1 to 4 carbon atoms), dihydroxy-alkyl (1 to 4 carbon atoms), cyanoalkyl, carbamoylalkyl, cycloalkyl of 3 to 7 carbon atoms, cycloalkyl (3 to 7 carbon atoms) -alkyl (1 to 4 atoms of carbon), 2-oxo-3- tetrahydrofuryl, alkoxy (1 to 4 รก carbon atoms) - alkyl (from 1 to 4 carbon atoms), alkoxy (from 1 to 4 carbon atoms) -carbonyl-cycloalkyl (from 3 to 7 carbon atoms), naphthylamino-alkyl (from 1 to 4 atoms of carbon), imidazolylamino-alkyl (from 1 to 4 carbon atoms), morpholinyl-alkyl (from 1 to 4 carbon atoms), pyrrolidinyl-alkyl (from 1 to 4 carbon atoms), piperidinyl-alkyl (from 1 to 4 carbon atoms) or cycloalkyl (from 3 to 7 carbon atoms) -amino-alkyl (from 1 to 4 carbon atoms), or R1 and R2, together with the nitrogen atom to which they are attached, form a morpholino, alkyl (from 1 to 4 carbon atoms) -piperazinyl, hydroxy-alkyl (from 1 to 4 carbon atoms) -piperazinyl, piperidinyl, pyrrolidinyl or p-chlorophenyl-alkyl (from 1 to 4 carbon atoms) -piperazinyl, in the form free base or acid addition salt. |