| abstract |
A heterocyclic compound in which s-triazine or pyrimidine is substituted with benzimidazole and morpholine, and which is represented by formula (I), or a pharmaceutically acceptable acid addition salt thereof: in which X and Y respectively represent atom of nitrogen, or one of them represents nitrogen atom and the other represents C-R7 where R7 represents hydrogen or halogen atom; R1, R2, R4, R5 and R6 represent hydrogen atom or C1-C6 alkyl; R3 represents morpholino (which may be substituted with one or two C1-C6 alkyl, trifluoromethyl, hydroxymethyl, monohalogenomethyl or -CH2NR8R9, wherein R8 represents hydrogen atom or C1-C6 alkyl and R9 represents hydrogen atom, (C1-C6 alkoxy ) -carbonyl or benzyl), piperidino (which may be substituted with hydroxy, acetoxy, oxo, ethylenedioxy or amino- (C1-C6 alkyl), piperazinyl (which may be substituted with C1-C6 alkyl), thiomorpholino, benzimidazolyl, cyano or -NR10R11 wherein R10 and R11 represent hydrogen atom, C1-C6 alkyl, hydroxy- (C1-C6 alkyl) or morpholino- (C1-C6 alkyl). |