| abstract |
The present invention relates to compounds of the formula (I), their stereochemical isomers, their N-oxide forms, or their pharmaceutically acceptable acid addition salts, R 1 is C 1-6 alkyloxy, C 2-6 alkenyloxy, or alkynyl- C2-6 oxy; R2 is hydrogen, C1-6 alkyl, C1-6 alkyloxy; R3 is hydrogen or halo; R4 is hydrogen or C1-6 alkyl; R5 is hydrogen or C1-6 alkyl; L is C3-6 cycloalkyl, C5-6 cycloalcanone, C2-6 alkynyl, or L is a radical of formula -A1-R6-, A1-X-R7, -A1-YC = O-R9, or -A1-YC (= O) -NR11R12 in which each A1 is C1-12 alkediyl; and R6 is hydrogen, cyano, C1-6 alkylsulfonylamino, C3-6 cycloalkyl, C5-6 cycloalcanone, or a heterocyclic ring system; R 7 is hydrogen, C 1-6 alkyl, C 1-6 hydroxyalkyl, C 3-6 cycloalkyl, or a heterocyclic ring system; X is O, S, SO2 or NR8, said R8 is hydrogen or C1-6 alkyl; R9 is hydrogen, C1-6 alkyl, C3-6 cycloalkyl, C1-6 alkyloxy, or hydroxy; And it is NR10 or a direct link; said R10 is hydrogen or C1-6 alkyl; R11 and R12 are each independently hydrogen, C1-6 alkyl, C3-6 cycloalkyl, or R11 and R12 combined together with the nitrogen atom may form an optionally substituted pyrrolidinyl, piperidinyl, piperazinyl or 4-morpholinyl ring. Methods for preparing said products, the formulations containing said products and their use as medicaments are described, in particular for treating disorders related to problems in gastric emptying. |