http://rdf.ncbi.nlm.nih.gov/pubchem/patent/ES-2210219-T3
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_6572ff5df928fd17340eb2a8cb6d8502 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-28 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P3-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D471-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P43-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-16 |
| classificationIPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D241-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D221-00 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P25-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P25-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P25-28 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P25-16 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D471-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-4985 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-5025 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P3-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P43-00 |
| filingDate | 2002-07-11-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2004-07-01-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_5fea8c6bced09794ee1569ccaef5b1e9 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_e4ecd4e7fa9251816223d3c866efd315 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_661249243e8d1b48087cbd49b39b2158 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_ef0b737a295d6412fe8a16bc04c6328e http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_bb63e32b4f7cc62ca7d8f599b80d6fc8 |
| publicationDate | 2004-07-01-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | ES-2210219-T3 |
| titleOfInvention | DERIVATIVES OF OCTAHIDRO-2H-PIRIDO- (1,2-A) -PIRAZINA, ITS PREPARATION PROCEDURE AND THE PHARMACEUTICAL COMPOSITIONS CONTAINING IT. |
| abstract | Octahydro-2H-pyrido- [1,2-a] -pyrazine derivatives, their preparation process and the pharmaceutical compositions containing them. The present invention relates to new octahydro-2H-pyrido- [1,2-a] -pyrazine derivatives, its preparation process and the pharmaceutical compositions containing them. The compounds of the present invention are particularly interesting from a pharmacological point of view for their specific interaction with the central histaminergic receptors of type H3, finding their application in the treatment of neuropathologies associated with brain aging, mood disorders, behavior food and sleep-insomnia rhythm, as well as his attention deficit hyperactivity syndrome. The aging of the population due to an increase in life expectancy has led to a large increase in the incidence of age-related neuropathologies and mainly Alzheimer's disease. The main clinical manifestations of brain aging and especially of age-related neuropathologies, are deficits of mnesic and cognitive functions that can lead to dementia. At the level of the central nervous system, recent neuropharmacological studies have shown that histamine through the central histaminergic systems played a role of neurotransmitter or neuromodulator in physiological or pathophysiological situations. Thus, it has been shown that histamine intervened in various physiological and behavioral processes such as thermoregulation, neuro-endocrine regulation, circadian rhythm, cataleptic states, motor skills, aggressiveness, eating behavior, learning and memorization, as well as synaptic plasticity. |
| priorityDate | 2001-07-12-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 441.