| abstract |
Cyclic depsipeptide as a chemotherapeutic agent against cancer. Serratamolide, also called cyclo[(3R)-3-hydroxydecanoyl-L-seryl-(3R)-3-hydroxydecanoyl-L-seryl], is a cyclic depsipeptide isolated from bacterial cultures of the species Serratia marcescens. Serratamolide decreases the viability of various cancer cells (leukemia, myeloma, carcinoma, etc.) and induces apoptosis in them, with practically no effect on non-cancer cells. This makes serratamolide, and its pharmaceutically acceptable addition salts and/or solvates, useful as an anticancer chemotherapeutic agent, particularly against leukemia, lymphoma, myeloma, carcinoma, melanoma, and sarcoma. |