http://rdf.ncbi.nlm.nih.gov/pubchem/patent/ES-2208098-A1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_e19ed5092514d4f22acfa3bc98b8b572 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D401-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D401-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D491-10 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D401-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D401-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D491-10 |
| filingDate | 2002-10-02-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_27de68369ac70e32b816699a830d82f0 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_7e0bad05a8c064bf507457f1e771417a http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_09210d17e3591de3019e2e7af7052a14 |
| publicationDate | 2004-06-01-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | ES-2208098-A1 |
| titleOfInvention | PROCEDURE AND INTERMEDIATES FOR OBTAINING DERIVATIVES FROM 1- (1H-BENCIMIDAZOL-2-IL) -4- (2-AMINOPIRIMIDIN) PIPERIDINE. |
| abstract | Procedure and intermediates for obtaining derivatives of 1- (1 H -benzimidazol-2-yl) -4- (2-aminopyrimidin) piperidine.n n n The process for obtaining derivatives of 1- (1 H -benzimidazol-2-yl) -4- (2-aminopyrimidin) piperidine (IV), where R 1 is hydrogen or 4-halobenzyl and R 5 is hydrogen, optionally substituted alkyl or benzyl, comprises the conversion of a 1- [1- (R 1) -1 H -benzimidazol-2-yl] -4- (R 2) (R 3) - piperidine (I), where one of R 2 or R 3 is hydroxy, optionally protected, or R 2 and R 3, independently of one another, are optionally substituted alkoxy or benzyloxy, or R_ { 2} and R 3 together form an alkylenedioxy group, optionally substituted, by hydrolysis and / or by oxidation in a 1- [1- (R 1) -1 H -benzimidazol-2-yl] -4-piperidone , which, by reductive amination (with optional separation of the intermediate imine formed) provides the corresponding amine, which, by reaction with a pyrimidine, yields said derivative of 1- (1 H -benzimidazol-2-yl) -4- (2 -aminopyrimidin) -piperidine (IV). |
| priorityDate | 2002-10-02-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 98.