| abstract |
THE COMPOSITIONS OF FORMULA I, IN WHICH B, D, E, R, W, Y, Z, B, C, D, E, F, GYH HAVE THE MEANINGS GIVEN IN THE CLAIMS, ARE INHIBITORS OF THE ADHESION AND MIGRATION OF LEUKOCYTES AND / OR ANTAGONISTS OF RECEIVERS OF ADHESION VLA 4 BELONGING TO THE GROUP OF INTEGRINES. THE INVENTION IS ABOUT THE USE OF FORMULA I COMPOSITIONS AND PHARMACEUTICAL PREPARATIONS CONTAINING SUCH COMPOSITIONS, INDICATED FOR THE TREATMENT AND PROFILAXIS OF DISEASES CAUSED BY EXTENDING IN AN UNWANTED WAY THE ADHESION OF LEUCOCITES AND / OR RELATIONSHIP, OR DISEASES IN WHICH INTERACTIONS OF CELL CELL OR CELL MATRIX THAT ARE BASED ON INTERACTIONS OF VLA 4 RECEIVERS WITH THEIR LIGANDS, FOR EXAMPLE IN INFLAMMATORY PROCESSES, Rheumatoid ARTHRITIS OR ALLERGIC DISEASES. THE INVENTION TESTS ALSO THE USE OF FORMULA I COMPOSITIONS FOR THE MANUFACTURE OF DRUGS INTENDED TO BE USED IN SUCH DISEASES. IT ALSO TRIES OF NEW COMPOSITIONS OF FORMULA I. |