| abstract |
AN ANTIFUNGIC AGENT OF FORMULA (I) OR A PHARMACEUTICALLY ACCEPTABLE SALT OF THE SAME IS DESCRIBED, IN WHICH AR IS A SUBSTITUTED PHENYLL GROUP WITH 1 TO 3 SUBSTITUTES, EACH SELECTED SELECTED FROM HALO AND CF SUB, 3}; YX IS A GROUP OF FORMULA (A), (B), (C), OR (D), IN WHICH Z IS HOF, AND IN WHICH HET IS AN AROMATIC HETEROCICLIC GROUP OF FIVE MEMBERS CONTAINING NITROGEN OPTIONALLY CONTAINING AN ATOM OXYGEN OR SULFUR AND THAT IS JOINED TO THE PHENYLL, PIRIDILE OR PYRIMIDINYL GROUP BY A CARBON OR NITROGEN ATOM AND THAT IS OPTIONALLY REPLACED BY 1 TO 3 SELECTED SUBSTITUTES EACH OF HALO; C SUB RENTAL, 1} - C SUB, 4}; (ALCOXI C SUB, 1} - C SUB, 4}) METHYL; 2 - (ALCOXI C SUB, 1} C SUB, 4}) ETOXIMETILO; 2 - HYDROXIETOXIMETILO; CYANOMETILO, NR SUP, 1} R SUP, 2} O CH SUB, 2} CONR SUP, 1} R SUP, 2}, WHERE R SUP, 1} YR SUP, 2} EACH ONE IS INDEPENDENTLY HO RENT C SUB, 1 } C SUB, 4}; PHENYLLY OR PHENYL (C SUB RENT, 1} - C SUB, 2}), BEING BOTH SUCH GROUP OPENINGLY REPLACED WITH HALO, TRIFLUOROMETILO OR RENT C SUB, 1} - C SUB, 4}; NHCO (C SUB RENTAL, 1} - C SUB, 4}); -NHSO SUB, 2} (C SUB RENTAL, 1} - C SUB, 4}); -NHCONR SUP, 1} R SUP, 2}, WHERE R SUP, 1} AND R SUP, 2} ARE AS DEFINED ABOVE; MERCAPTO; S (O) SUB, N} (RENT C SUB, 1} - C SUB, 4}), WHERE N IS 0, 1 OR 2. |