| abstract |
THE INVENTION IS ABOUT INHIBITORS OF THE UNION THROMBIN OF NON-SLOW FORMULA: A - B - C - LYS - D, IN WHICH A IS H, 2 HYDROXY - 3 - CYCLOHEXILPROPIONILO -, R 1, R 1 - OR CO -, R 1 - CO -, R 1 - SO 2 -, (CHR 2) N COOR 3, OR AN N PROTECTIVE GROUP, R 1 being SELECTED BETWEEN - RENT (C 1 - 6) - COOH, RENT (C 1 - 12 ), ALQUENILO (C 2 - 12), ARILO (C 6 - 14), ARALQUILO (C 7 - 15) AND ARALQUENILO (C 8 - 16), THE ARILO GROUPS SUBSTITUTED WITH RENT (C 1 - 6), ALCOXI ( C 2 - 12), HYDROXY OR HALOGEN; R 2 IS HO HAS THE SAME MEAN THAT R 1, R 3 IS SELECTED BETWEEN H, RENT (C 1 - 12), RENT (C 2 - 12), ARILO (C 6 - 14), ARALQUILO (C 7 - 15) AND ARALQUENILO (C 8 - 16), THE ARILO GROUPS SUBSTITUTED WITH RENT (C 1-6), ALCOXI (C 2 - 12), HYDROXY OR HALOGEN; N IS A WHOLE NUMBER OF 1 TO 3; B IS A LINK, L - ASP OR AN ESTER DERIVATIVE OF THE SAME, LEU, NORLEU, - N (BENCILO) - CH 2 - CO, - N (2 - INDANO) - CH 2 - CO -, D - 1 - PIQ , D - 3 - PIQ, D - TIQ, ATC OUN D - AMINO ACID PRESENTING A HYDROPHOBO AROMATIC SIDE CHAIN; C ES AZT, PRO, PEC, NORLEU (CYCLE) GLY, A FORMULA AMINO ACID - N [CYCLALKYL (C 3 - 8)] - CH 2 CO - O - N (BENCILO) - CH 2 - CO -, D IS SELECTED IN TRE COOH, TETRAZOL, OXAZOL, TIAZOL AND BENZOTIAZOL, OAYC PRESENT THE MEANINGS MENTIONED ABOVE, B ES D CICLOALQUILALANINA (C 3 - 8), AND D IS TETRAZOL, OXAZOL, TIAZOL OR BENZOTIAZOL; OR A PROPHARM OF THE SAME; OR A PHARMACEUTICALLY ACCEPTABLE SALT OF THE SAME; WITH THE EXCEPTION OF THE ME - D - PHE - PRO - LYS - COOH COMPOUND. THE COMPOUNDS CAN BE USED AS ANTHROMBOTIC AGENTS. |