| abstract |
The tetrahydropyridines (or 4-hydroxypiperidines) -butylazoles (I) derivatives, where R1, R2 and R3, the same or different, each represent hydrogen, halogen, C1-C4 alkyl, trifluoromethyl, hydroxy, alkoxy, or two Adjacent radicals can form a cycle; A represents an atom of C and the dotted line represents an additional bond, or A represents an atom of C attached to a hydroxyl group and the dotted line represents lack of additional bond; Z1 is N or CR4; Z2 is N or CR5; Z4 is N or CR7; and R4, R5, R6 and R7, the same or different, represent hydrogen, halogen, C1-C4 alkyl, aryl or substituted aryl, or two adjacent radicals can be part of another cycle, are useful for the treatment of acute pain, neuropathic pain, or nociceptive pain in mammals, including man. |