| abstract |
THE PRESENT INVENTION REFERS TO DERIVATIVES OF 2 CYANOIMINOIMIDAZOL OF FORMULA (I), TO ITS N-OXIDE FORMS, ITS PHARMACEUTICALLY ACCEPTABLE ADDITION SALTS AND ITS STEREOCHEMICALLY ISOMERIC FORMS, WHERE R 1 YR 2 EVERY ONE, NEXT ONE C 1-6, DIFLUOROMETILO, TRIFLUOROMETILO, CICLOALQUILO C 3-6, A HETEROCIC OF 5, 6 OR 7 MEMBERS, CONTAINING ONE OR TWO HETEROATOMOS SELECTED FROM OXYGEN, SULFUR OR NITROGEN; INDANIL; 6,7 - DIHIDRO - 5H - CYCLOPENTAPIRIDINYL; BICYCLE [2.2.1] - 2 - HEPTENYL; BICYCLE [2.2.1] HEPTANYL; C 1-6 ALQUILSULFONILO; ARILSULFONYL OR RENT C 1-10 REPLACED; R 3 IS HYDROGEN, HALO OR ALQUILOXI C 1-6; R 4 IS HYDROGEN, HALO, RENT C 1-6, TRIFLUOROMETILO; CYCLEALKYL C SUB, 3-6; CARBOXYL; C 1-4 ALCOXICARBONYL; CARBON Cyl Cycloalkylamino C 36; Aryl; HET 1; OR RENT C 1-6 REPLACED; O R 4 ES-O-R 7 O-NH-R 8; R S UP, 5 IS HYDROGEN, HALO, HYDROXYL, C 1-6 RENT OR C 1-6 RENT; R 6 ES HYDROGENOO RENT C 1-4; O R 4 Y R 6 O R 4 Y R 5, JOINTLY, MAY FORM A BIVALENT RADICAL; - A - B - ES - CR 10 = CR 11 - O - CHR 10 CHR 11 -; L IS HYDROGEN; C 1-6 RENT; C 1-6 alkylcarbonyl; ALQUILOXICARBONI LO C 1-6; RENT C 1-6 REPLACED; C 3-6 ALKYLENE; C 3-6 REPLACED SUBSTITUTE; PIPERIDINYL; PIPERIDIN ILO REPLACED; C 1-6 RENT SULFONYL OR ARYL SULFONYL. THESE COMPOUNDS PRESENT INHIBITING ACTIVITY OF PDE IV AND OF CYTOQUINE. THE INVENTION REFERS TO THE PROCEDURES FOR THE PREPARATION OF FORMULA COMPOUNDS (I) AND PHARMACEUTICAL COMPOSITIONS OF THE SAME. |