abstract |
Method for the preparation of citalopram, which comprises the reaction of a compound of Formula (IV), wherein R is halogen, or -CF3 - (CF2) -SO2-, being n O to 8, with a cyanide source, in presence of a palladium catalyst and a catalytic amount of Cu 0 Zn2 +, or with Zn (CN) 2 in the presence of a palladium catalyst. |