http://rdf.ncbi.nlm.nih.gov/pubchem/patent/ES-2193664-T3
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_f2d3599fb8f8f479dba95ca9bb504884 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-505 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P31-18 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D403-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P31-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D239-80 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D239-47 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-5513 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P31-18 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-513 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-506 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-505 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D239-42 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D403-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-675 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D239-50 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D239-48 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D239-47 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D239-46 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-5513 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-715 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-551 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D401-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D- http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D239-80 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K- |
| filingDate | 1999-11-01-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2003-11-01-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_f3ccb0d84506e3b24880608cb3e4010a http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_fd353bc9b009350567061c9d0ce4b4a2 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_365d6c008ac0e8dce16ca0477eba79ba http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_7757ef2d4bf123ae90dbdd758418436c http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_5ad34b861ad2e616348197a155504f17 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_39c877cd5f3e3d1693817ca5555b717a |
| publicationDate | 2003-11-01-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | ES-2193664-T3 |
| titleOfInvention | PYRIMIDINES INHIBITORAS OF THE REPLICATION OF HIV. |
| abstract | This invention relates to the use of compounds of formula * formula * N-oxides, pharmaceutically acceptable addition salts, quaternary amines and stereoisomeric forms thereof, in which -a {sup, 1} = a { sup, 2} -a {sup, 3} = a {sup, 4} - form a phenyl, pyridinyl, pyrimidinyl, pyridacinyl or pyrazinyl group with the vinyl group to which you are attached; n is from 0 to 4 and possibly 5; R {sup, 1} is hydrogen, aryl, formyl, C {sub, 1-6} alkylcarbonyl, C {sub, 1-6} alkyl, C {sub, 1-6} alkyloxycarbonyl, C {sub, 1- alkyl 6} substituted, or C {sub, 1-6} alkyloxy C {sub, 1-6} alkylcarbonyl; each R {sup, 2} is independently hydroxy, halo, optionally substituted C {sub, 1-6} alkyl, C {sub, 2-6} alkenyl or C {sub, 2-6} alkynyl, C {cycloalkyl sub, 3-7}, C {sub, 1-6} alkyloxy, C {sub, 1-6} alkyloxycarbonyl, carboxyl, cyano, nitro, amino, mono- or C {sub, 1-6} dialkylamino, polyhalomethyl, polyhalomethyloxy, polyhalomethylthio, -S (= O) {sub, p} R {sup, 6}, -NH-S (= O) {sub, p} R {sup, 6}, -C (= O) R { sup, 6}, -NHC (= O) H, -C (= O) NHNH {sub, 2}, -NHC (= O) R {sup, 6}, -C (= NH) R {sup, 6 } or a 5-membered heterocyclic ring; p is 1 or 2; L is an optionally substituted C {sub, 1-10} alkyl, C {sub, 2-10} alkenyl, C {sub, 2-10} alkynyl or C {sub, 3-7} cycloalkyl; or L is -X-R {sup, 3}, where R {sup, 3} is an optionally substituted phenyl, pyridinyl, pyrimidinyl, pyrazinyl or pyridacinyl; X is -NR {sup, 1} -, -NH-NH-, -N = N-, -O-, -C (= O) -, -CHOH-, -S-, -S (= O) - or -S (= O) {sub, 2} -; Q is hydrogen, C {sub, 1-6} alkyl, halo, C {sub, 1-6} polyhaloalkyl or an optionally substituted amino group; Y represents hydroxy, halo, C {sub, 3-7} cycloalkyl, optionally substituted C {sub, 1-6} alkyl, C {sub, 2-6} alkenyl or C {sub, 2-6} alkynyl, C alkyloxy {sub, 1-6}, C {sub, 1-6} alkyloxycarbonyl, carboxyl, cyano, nitro, amino, mono- or dialkylamino C {sub, 1-6}, polyhalomethyl, polyhalomethyloxy, polyhalomethylthio, -S (= O ) {sub, p} R {sup, 6}, -NH-S (= O) {sub, p} R {sup, 6}, -C (= O) R {sup, 6}, -NHC (= O) H, -C (= O) NHNH {sub, 2}, -NHC (= O) R {sup, 6}, - C (= NH) R {sup, 6} or aryl; the aryl is optionally a substituted phenyl; Het is an optionally substituted heterocyclic radical; for the manufacture of a medicament for the treatment of subjects suffering from HIV infection (human immunodeficiency virus). |
| priorityDate | 1998-11-10-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 48.