| abstract |
The invention relates to new 1,2,3,4-tetrehydenaphthalene derivatives substituted by piperidyl or piperazinyl having formula (I) in which X is N or CH; Y is NR {sub, 2} CH {sub, 2}, CH {sub, 2} NR {sub, 2}, NR {sub, 2} -CO, CO-NR {sub, 2}, or NR {sub , 2} SO {sub, 2} in which R {sub, 2} is H or C {sub, 1-6} alkyl; R {sub, 1} is H, C {sub, 1-6} alkyl, or C {sub, 3-6} cycloalkyl; R {sub, 3} is C {sub, 1-6} alkyl, C {sub, 3-6} cycloalkyl- (CH {sub, 2}) {sub, n}, in which the aryl is phenyl or a heteroaromatic ring containing one or two heteroatoms selected from N, O and S and which can be mono or disubstituted, n is 0-4; R {sub, 9} is C {sub, 1-6} alkyl, C {sub, 3-6} cycloalkyl, OCF {sub, 3}, OCFH {sub, 2}, OCH {sub, 2} F, halogen , CN, CF {sub, 3}, OH, C {sub, 1-6} alkoxy, C {sub, 1-6} C {sub, 1-6} alkyl, NR {sub, 6} R {sub , 7}, SO {sub, 3} CH {sub, 3}, SO {sub, 3} CF {sub, 3}, SO {sub, 2} NR {sub, 6} R {sub, 7}, and a substituted or unsubstituted heterocyclic or heteroaromatic ring containing one or two heteroatoms selected from N and O, wherein the substituents are C {sub, 1-6} alkyl; or COR {sub, 8}; wherein R {sub, 6}, R {sub, 7} and R {sub, 8} are as defined above, The invention also relates to (R) -enantiomers, (S) -enantiomers or racemates in the form of free base or pharmaceutically acceptable salts of these derivatives, to a process for their preparation, the pharmaceutical compositions containing said therapeutically active compounds and the use of said active compounds in therapy. |