http://rdf.ncbi.nlm.nih.gov/pubchem/patent/ES-2184561-A1

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filingDate 2000-06-13-04:00^^<http://www.w3.org/2001/XMLSchema#date>
inventor http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_5cbb6f2eae03b049f510d140eb80642d
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publicationDate 2003-04-01-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber ES-2184561-A1
titleOfInvention SOLID PHARMACEUTICAL FORM OF WATER DISPERSABLE ORAL ADMINISTRATION FOR THE TREATMENT OF TUBERCULOSIS CONTAINING REFAMPICINE, ISONIAZIDA, PYRAZINAMIDE AND HYDROCHLORINE PYRIDOXINE, PROCEDURE FOR OBTAINING AND FORM OF PRESENTATION FORM.
abstract Solid pharmaceutical form for oral administration dispersible in water for the treatment of tuberculosis containing rifampicin, isoniazid, pyrazinamide and pyridoxine hydrochloride, procedure for obtaining it and form of presentation of said pharmaceutical form. The pharmaceutical form contains rifampicin, isoniazid, pyrazinamide and pyridoxine hydrochloride as active principles, in a solid granular matrix dispersible in water, which once reconstituted in water gives rise to a pleasant-tasting suspension. The production process comprises the simple mixture of the components or obtaining, separately, some granules of rifampicin and others of isoniazid and pyrazinamide, and, optionally, pyridoxine hydrochloride, mixing and homogenizing said granules. The pharmaceutical form is suitable for making a presentation form of a medicament containing rifampicin, isoniazid, pyrazinamide and pyridoxine hydrochloride, for example, in the form of single-dose sachets containing said pharmaceutical form in a therapeutically effective dosage.
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