http://rdf.ncbi.nlm.nih.gov/pubchem/patent/ES-2182531-T3
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_f2d3599fb8f8f479dba95ca9bb504884 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D249-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D249-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D231-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D233-56 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P31-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P31-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P31-00 |
| classificationIPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D319-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D295-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D249-00 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D417-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-5377 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-541 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D405-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D405-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D405-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D521-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P31-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D249-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P31-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-497 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-496 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-495 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D413-14 |
| filingDate | 1999-05-06-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2003-03-01-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_fd353bc9b009350567061c9d0ce4b4a2 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_622e2b26049c4235b63c4a1dfdee08b5 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_d0594c23742091c106eb158ec1988ea8 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_571d790e60f8c52da323e4d6997ae3f4 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_0d411a6a06c8dec7de1e15cebd074c27 |
| publicationDate | 2003-03-01-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | ES-2182531-T3 |
| titleOfInvention | WATER SOLUBLE AZOLES AS SPECTRO ANTIFUNGICOS. |
| abstract | A compound of the formula a form of Nóxide, a pharmaceutically acceptable addition salt or a stereochemically isomeric form thereof, in which L represents a radical of the formula or in which each Alk independently represents C1.6 optionally substituted alkanediyl with hydroxy or C1-4alkyloxy; each n is independently 1, 2 or 3; Y represents O, S or NR2; each R1 independently represents hydrogen, aryl, Het1, or C1.6alkyl optionally substituted with one, two or three substituents independently selected from halo, hydroxy, mercapto, C1-4alkyloxy, C1-4alkylthio, aryloxy, arylthio, arylC1-4 alkyloxy, arylC1-4alkylthio, cyano, amino, mono¿ or di (C1-4alkyl) amino, mono¿ or di (aryl) amino, mono¿ or di (arylC1-4alkyl) amino, C1-4alkyloxycarbonylamino, benzyloxycarbonylamino, aminocarbonyl, carboxyl, C1-4alkyloxycarbonyl, guanidinyl, aryl or Het2; each R2 independently represents hydrogen or C1.6alkyl; or in the case where R1 and R2 are attached to the same nitrogen atom, they can be considered together to form a heterocyclic radical selected from morpholinyl, pyrrolidinyl, piperidinyl, homopiperidinyl or piperazinyl; said heterocyclic radical may be optionally substituted with C1-4alkyl, aryl, Het2, arylC1-4alkyl, Het2C1-4alkyl, hydroxyC14alkyl, amino, mono- or di (C1-4alkyl) amino, aminoC1-4alkyl, mono- or di (C1¿ 4alkyl) aminoC1-4alkyl, carboxyl, aminocarbonyl, C1-4alkyloxycarbonyl, C1-4alkyloxycarbonylamino or mono- or di (C1-4alkyl) aminocarbonyl; or they can be considered together to form an azido radical; each R3 independently represents hydrogen, hydroxy or C1-4alkyloxy; aryl represents phenyl, naphthalenyl, 1,2,3,4-tetrahydrophthalenyl, indenyl or indanyl; each of said aryl groups may optionally be substituted with one or more substituents selected from halo, C1-4alkyl, hydroxy, C1-4alkyloxy, nitro, amino, trifluoromethyl, hydroxyC1-4alkyl, C1-4alkyloxyC1-4alkyl, aminoC1-4alkyl, mono Or di (C1-4alkyl) aminoC1-4alkyl; Het1 represents a monocyclic or bicyclic heterocyclic radical; selected said monocyclic heterocyclic radical pyridinyl, piperidinyl, homopiperidinyl, pyrazinyl, pyrimidinyl, pyridazinyl, triazinyl, triazolyl, pyranyl, tetrahydropyranyl, imidazolyl, imidazolinyl, imidazolidinyl, pyrazolyl, pyrazolinyl, pyrazolidinyl, thiazolyl, thiazolidinyl, isothiazolyl, oxazolyl, oxazolidinyl, isoxazolyl , pyrrolyl, pyrrolinyl, pyrrolidinyl, furanyl, tetrahydrofuranyl, thienyl, thiolanyl, dioxolanyl; said bicyclic heterocyclic radical being selected from the quinolinyl group, 1,2,3,4 tetrahydroquinolinyl, isoquinolinyl, quinoxalinyl, quinazolinyl, phthalazinyl, cinnolinyl, chromanyl, thiochromanyl, 2 H, chromenyl, 1,4, benzodioxanyl, indolyl, isool, isool, indolyl , indazolyl, purinyl, pyrrolopyridinyl, furanopyridinyl, thienopyridinyl, benzothiazolyl, benzoxazolyl, bencisothiazolyl, bencisoxazolyl, benzimidazolyl, benzofuranyl, benzothienyl; wherein each of said mono- or bicyclic heterocycles may be optionally substituted with one or, if possible, more substituents selected from halo, C1-4alkyl, hydroxy, C1-4alkyloxy, nitro, amino, trifluoromethyl, hydroxyC1¿ 4alkyl, C1-4alkylloxyC1-4alkyl, aminoC1-4alkyl, mono- or di (C1-4alkyl) aminoC1-4alkyl, aryl or arylC1-4alkyl; Het2 is the same as Het1 and can also be a monocyclic heterocycle selected from piperazinyl, homopiperazinyl, 1,4-dioxanyl, morpholinyl, thiomorpholinyl; wherein each of said monocyclic heterocycles optionally substituted with one or, if possible, more substituents selected from halo, C1-4alkyl, hydroxy, C1-4alkyloxy, nitro, amino, trifluoromethyl, hydroxyC1-4alkyl, C1 4-AlkyloxyC1-4alkyl, aminoC1-4alkyl, mono- or di (C1-4alkyl) aminoC1-4alkyl, aryl or arylC1-4alkyl; R6 represents hydrogen or C1-4alkyl; R7 represents hydrogen or C1-4alkyl; or R6 and R7, considered together, form a bivalent radical of the formula ¿R6¿R7¿, in whose formula ¿R6¿R7¿ is: ¿N = CH¿ (i), ¿CH = N¿ (ii), ¿CH = CH¿ (iii), ¿CH2¿CH2 (iv), in whose formulas a hydrogen atom in radicals (i) and (ii) can be replaced with a C1-4 alkyl radical and one or more hydrogen atoms in radicals (iii) and (iv) it can be replaced by a C1-4alkyl radical; D represents a radical of formula in which formulas X is N or CH; R4 is hydrogen or halo; R5 is halo. |
| priorityDate | 1998-05-14-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 69.