| abstract |
THE INVENTION REFERS TO A FORMULA COMPOUND (I) AND ITS PHARMACEUTICALLY ACCEPTABLE SALTS, WHERE 1 AND SUP, 2 ARE BOTH THERE; X ES CO, S (O) 2 O S (O) - (CH 2) SUB, N WHERE THE ATOM OF S IS DIRECTLY CONNECTED TO THE PHENYL AND N IS 0, 1 OR 2; YR 1 EN 8 - AZABICICLO [3,2,1] OCTILO, QUINUCLIDILO, BICICLO [3.3.0] OCTILO, CICLOALQUILO C 3-10, 2, 3, 5, 6 TETRAHYDRO - 4H - TIOPIRANILO OR CICLOALQUIL C 3-6 ALQUILO C 1-4, OPTIONALLY REPLACED BY C SUB RENT, 1-4, HYDROXYL, DIOXARANYL OR OXO. THE NEW DIHYDROXIPIRIDINE COMPOUNDS OF THE PRESENT INVENTION HAVE EXCELLENT ANTAGONIST ACTIVITY OF BRADIQUININE AND ARE, THEREFORE, USEFUL FOR THE TREATMENT OF MEDICAL ALTERATIONS CAUSED BY BRADIQUININE, AS THE INFLAMMATION, CARDIOVASTIC DISTRICT, ALARM, BODYDAYS , BURNS, VIRAL INFECTIONS, INJURIES IN THE HEAD, MULTIPLE OR SIMILAR TRAUMATISM, IN MAMMALS, ESPECIALLY IN HUMANS. |