| abstract |
PYRIMIDINES AND TRIAZINES OF FORMULA (I), WHERE R IS RENT C 1-6, AMINO, MONO- OR DIALQUIL C 1-6 AMINO; R 1 IS HYDROGEN, C 1-6 RENT, C 3-6 RENT, C 1-6 HYDROXIAL RENT OR C 1-6 RENT - C 16 RENT; R 2 IS C 1-6 RENT, MONO- OR DYCYCAL CENT B, 3-6 METHYL, PHENYLMETILE, REPLACED PHENYLMYTIME, RENTROXI C1-6 - RENT C 1-6, HYDROXIALQUIL C 1-6, RENT C 1-6 OXICARBONYL C 1-6 ALKYL C 3-6; OR R 1 AND R 2 TOGETHER WITH THE NITROGEN TO WHICH THEY ARE UNITED CAN FORM A PIRROLIDINYL, MORPHOLINYL OR PIPERIDINYLL GROUP; X ES N O CR 3; R 3 IS HYDROGEN OR RENT C 1-6; R 4 IS PHENYLL OR REPLACED PHENYL; A ES - C (= O) -, (A), O - CR 7 R 8 - WHERE R 5 AND R 6 S ON EACH INDEPENDENTLY HYDROGEN OR RENT C 1-4; R 7 IS HYDROGEN OR OH; R 8 IS HYDROGEN OR RENT C SUB, 1-6; THAT HAVE ANTAGONISTIC PROPERTIES OF CRF RECEPTORS; PHARMACEUTICAL COMPOSITIONS CONTAINING THESE COMPOUNDS AS ACTIVE PRINCIPLES; METHODS TO TREAT DISORDERS RELATED TO HYPERSECRETION OF CRF SUCH AS DEPRESSION, ANXIETY AND ABUSE OF SUBSTANCES, BY ADMINISTRATION OF AN EFFECTIVE AMOUNT OF A FORMULA COMPOUND (I). |