| abstract |
THE INVENTION PROVIDES FORMULA (I) COMPOUNDS AND THE PHARMACEUTICALLY ACCEPTABLE SALTS OF THE SAME, IN WHICH R IS A HETEROARILO GROUP WITH A RING OF 5 LINES THAT CONTAIN 3 OR 4 NITROGEN HETEROATOMS, WHICH IS IN THE MIDDLE OF THE MIDDLE A CARBON OR NITROGEN RING OF THE RING, OR IS AN HETEROARILO GROUP WITH A RING OF 6 LINKS CONTAINING BETWEEN 1 AND 3 NITROGEN HETEROATOMS THAT IS JOINED TO THE QUINOXALINDIONA RING THROUGH A CARBON OPPORTUNITY CONDENSED AND OPTIONALLY SUBSTITUTED, INCLUDING IN THE CONDENSED BENZO PORTION, BY MEANS OF 1 OR 2 SUBSTITUTES, SELECTED EACH OF THEM INDEPENDENTLY BETWEEN RENT C SUB, 1 -C 4, ALQUENILO C 2 -C 4, CYCALOQUIL, 7 HYDROXI, ALCOXI C 1 -C 4, OXICICLOALQUILO C 3 -C 7, -COOH, ALCOXICARBONILO C 1 -C 4, CONR 3 R 4, -N 3 R 4, -S (O) P (RENT C 1 -C 4 ), -SO 2 NR 3 R 4, ARI LO, OXIARILO, ARILALCOXI (C 1 -C 4 ) YHET, BEING SUCH A RENT C 1 -C 4 OPTIONALLY REPLACED WITH CIC LOALQUILO C 3 -C 7, HALOGEN, HIDROXI, ALCOXI C 1-C 4, HALOALCOXI (C 1 -C 4), OXICICLOALQUILO C SUB, 3 C 7, C 3 -C 7-CYCALCYL 7 ALCOXI C 1 C4), -COOH, ALCOXI C 1 -C 4 CARBONYL, CONR 3 R 4, -NR 3 R 4, -S (O) P (C 1 -C 4 RENT), - SO 2 (ARILO), SO 2 NR 3 R 4, MOR FOLINO, ARILO, OXIARILO, ARILALCOXI (C 1 -C 4) OR HET, BEING SUCH ALKYLENE C 2 -C 4 OPTIONALLY REPLACED WITH ARILO; R 1 AND R 2 EACH ONE OF THEM IS SELECTED INDEPENDENTLY BETWEEN H, FLUOROUS, CHLORINE, SPRAY, RENT C 1 -C SUB.4 AND HALOALQUILO C 1 -C SUB.4; R 3 AND R 4 EACH ONE OF THEM IS SELECTED INDEPENDENTLY BETWEEN H AND I RENT C 1 C 4 OR, WHEN THEY JOIN, THEY ARE HERE LENO C 5 -C 7; P ES 0, 1 OR 2; TOGETHER WITH THE PREPARATION OF THE COMPOSITIONS THAT CONTAIN THEM, THE USES OF AND THE INTERMEDIATES USED IN THE SYNTHESIS OF SUCH COMPOUNDS. THE COMPOUNDS ARE USEFUL AS ANTAGONISTS OF THE NMDA RECEIVER FOR THE TREATMENT OF ACUTE NEURODEGENERATIVE AND CHRONIC NEUROLOGICAL DISORDERS. |