| abstract |
THE INVENTION CONCERNS INHIBITORS OF THE METALOPROTEASE OF THE MATRIX, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM, AND A PROCEDURE FOR THE USE OF THEM TO TREAT DIFFERENT PHYSIOLOGICAL STATES. THE COMPOUNDS OF THE INVENTION SUBMIT THE GENERAL FORM (I), WHERE R 1 REPRESENTS RENT C 6 C 12; ALCOXI C 5-C 12; RENT IO C 5 C 12; A POLYETER OF FORMULA R 2 O (C 2 H 4 O) A -, WHERE A IS 1 OR 2; AND R 2 IS ALQU ILO C 1 - C 5, PHENYL OR BENCILO; AND SUBSTITUTED RENT OF FORMULA R 3 (CH 2) B - C C -; WHERE B IS 1-10 AND R 3 IS H -, HO - O R 4 O -, WHERE R 4 IS RENT C 1 - C 3, PHENYL OR BENCILO. THE FRACC IONES RENT, PHENYL AND BENCILO OF R 1 CAN CARRY AT LEAST A PHARMACEUTICALLY ACCEPTABLE SUBSTITUTE. SUB-INDEX N IS 2-4. R 5 REPRESENTS PHENYL; IMIDOILO OF 4-12 CARBON ATOMS; (3H) - BENZO - 1,2,3 - TRIAZIN - 4 - ON - 3 - ILO; N - SACARINYL; (2H) - FTALACIN - 1 -ON - 2 - ILO; 2 - BENZOXAZOLIN - 2 - ON - 3 ILO; 5,5 - DIMETILOXAZOLIDINA - 2,4 -DION - 3 - ILO; AND TIAZOLIDIN 2,4 - DION - 3 - ILO; BEING ABLE TO CARRY FENYL AND BENZO FRACTIONS OF R 5 AT LEAST A PHARMACEUTICALLY ACCEPTABLE SUBSTITUTE. PHARMACEUTICALLY ACCEPTABLE SALTS OF SUCH MATERIALS ARE ALSO INCLUDED. |