abstract |
4-AMINO-BENZOILOGUANIDINAS OF FORMULA I, WHERE R 1 IS A, CF {SUB, 3}, CH {SUB, 2} OR C {SUB, 2} F {SUB, 5}; R {SUP, 2} YR {SUP, 3} ARE INDEPENDENTLY ONE OF ANOTHER, H, A, CYCLALQUIL WITH 3 TO 7 CARBON, PH OR HET, R {SUP, 2} YR {SUP, 3} ARE THE TWO TOGETHER RENTED WITH 4 TO 5 ATOMS OF C, HET A HETEROCICLE OF ONE OR TWO RINGS, SATURATED, UNSATURATED OR AROMATIC, WITH 1 TO 4 ATOMS OF N, OY / OR SULFUR, UNITED WITH NOC, INSTITUTED OR REPLACED ONE, TWO OR THREE TIMES BY HAL, CF {SUB, 3}, A, OH, SH, SA, NH {SUB, 2}, NHA, NA {SUB, 2}, CN, NO {SUB, 2} AND / OR CARBONYL OXYGEN; A IS RENT WITH 1 TO 6 ATOMS OF C; HAL IS F, CL, BR OR IODO; AND PH IS AN UNUSED OR REPLACED PHENYL ONE, TWO OR THREE TIMES BY A, OA, NH {SUB, 2}, NHA, NA {SUB, 2}, F, CL, BR, AND / OR CF {SUB, 3} , AS WELL AS ITS PHYSIOLOGICALLY ACCEPTABLE SALTS. THEY HAVE ANTIARRITHMIC PROPERTIES AND ACT AS INHIBITORS OF THE ANTIPORTER CELLULAR NA {SUP, +} / H {SUP, +}. |