| abstract |
THE PRESENT INVENTION PROVIDES NEW COMPOUNDS OF FORMULA (I), N-OXIDES, STEREOCHEMICALLY ISOMERIC FORMS, AND ACID, PHARMACEUTICALLY ACCEPTABLE, ADDITIONAL SALTS OF THE SAME. IN FORMULA (I), AYB, UNITED, FORM A BIVALENT RADICAL OF FORMULA: -N = CH- (A), -CH = N- (B), CH {SUB, 2} -CH {SUB, 2} - (C), CH = CH- (D), -C (= O) -CH {SUB, 2} - (E), -CH {SUB, 2} -C (= O) - (F); R {SUP, 1} IS HYDROGEN, RENT C {SUB, 1-6}, OR HALO; R {SUP, 2} IS HYDROGEN OR HALO; R {SUP, 3} IS HYDROGEN; C {SUB, 1-8}, C {SUB, 3-6} CYCLE-RENT OR C {SUB, 1-8} RENT REPLACED WITH HYDROXY, OXO, C {SUB, 3-6} CYCAL-RENT OR ARYL. HET IS A FIVE OR SIX MEMBER, OPTIONALLY REPLACED RING. IT IS ALSO DESCRIBED ITS USE AS A MEDICINE, ESPECIALLY AS A LIPID REDUCING AGENT, AS WELL AS PHARMACEUTICAL COMPOSITIONS AND PROCEDURES FOR THE PREPARATION OF SUCH COMPOUNDS AND COMPOSITIONS. |