| abstract |
Isosorbide mononitrate derivatives and their use as vasodilator agents with decreased tolerance. Novel isosorbide mononitrate derivatives and their pharmaceutically acceptable salts are described, which have vasodilator activity with a decreased tolerance effect, of general formula (I) in which A and B represent indistinctly any of the groups -ONO sub, 2 and - Z-CO-R, where Z is an oxygen or sulfur atom, and R is an alkyl group C sub, 1 -C sub, 4, aryl or aralkyl, optionally substituted, or the group in which R sup, 1 is hydrogen or an alkyl group C sub, 1 -C sub, 4, aryl or aralkyl, possibly substituted, so that always one of A or B is -ONO sub, 2, but never both at the same time, when Z is an atom sulfur R is an alkyl group C sub, 1 -C sub, 4, aryl or aralkyl, optionally substituted, and when Z is an oxygen atom R is the group |