http://rdf.ncbi.nlm.nih.gov/pubchem/patent/ES-2138535-A1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_c2b9dc89cc4ba060cc73bbf0c90bbb78 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D473-18 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-52 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D473-40 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D473-32 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D473-24 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D473-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D473-00 |
| filingDate | 1997-07-18-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_55f680f4a031fad8412c0d4a9e1106ff http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_2eb7ae4060d922fb3c0460ed867230b2 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_6ea14be947845165faf23fadbd26392b |
| publicationDate | 2000-01-01-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | ES-2138535-A1 |
| titleOfInvention | PROCEDURE FOR THE PREPARATION OF THE ANTIVIRAL COMPOUNDS PENCICLOVIR AND FAMCICLOVIR. |
| abstract | Procedure the preparation of the antiviral compounds penciclovir and famciclovir. A process for the preparation of penciclovir or famciclovir comprising one or more of the following steps: a) forming a purine by imidazole or pyrimidine ring closure; b) reacting a purine with a suitable 9-side chain precursor intermediate; c) converting the side chain at position 9 to 4-hydroxy-3-hydroxymethylbut-l-yl or 4-acetoxy-3-acetoxymethylbut-l-yl d) converting a purine to guanine or 2-aminopurine; characterized in that the purine has the formula (I): in which X{sub,1, is SH or S-Z-R{sub,3, (Z is optional) and is straight or branched chain alkylene and R{sub,3 is alkyl , aryl or heteroaryl, X{sub,2 is SH, hydrogen, or a group that can be converted thereto; R{sub,1 , is amino or a group that can be converted to it; and R{sub,2, is hydrogen or a side chain precursor at position 9. Said purine of formula (T) is converted to famciclovir or penciclovir by subsequent transformations. |
| priorityDate | 1996-07-20-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 39.