| abstract |
Novel 2,3-benzodiazepine derivatives The invention relates to non-competitive AMPA antagonist compounds of formula I, in which R {sup, 1 and R {sup, 2 independently represent a hydrogen, a halogen, a group C { sub, 1-4 -alkyl, a C {sub, 1-4 -alkoxy group, a nitro group, a trifluoro-methyl group or a secondary amine group R {sup, 3 represents a C {sub group, 1-4 -alkyl, a C {sub, 3-5 -cycloalkyl group or a ketocarbonyl group R {sup, 4 and R {sup, 5 independently signify a hydrogen or a C {sub, 1-3 alkyl, R {sup group , 6 and R {sup, 7 are independently hydrogen, chlorine or bromine. as well as the isomers and acid addition salts of the compounds or isomers, and the pharmaceutical compositions prepared from any of them. The invention also relates to the starting compounds of formula II, in which R {sup, 1, R {sup, 2, R {sup, 4, R {sup, 5, R {sup, 6 and R { sup, 7 have the meaning indicated in relation to formula I. |