| abstract |
Benzopyranic derivatives with leukotriene antagonist action, procedure for their preparation and use thereof. The invention describes derivatives of formula I, A is an oxygen atom, sulfur or a methylene group; B and C are: a) when B is a benzofused heterocycle, U is an oxygen, sulfur or nitrogen atom, Z-Y are carbon atoms linked by a single or double bond and T is a single bond, a methylene or carbonyl group, C can be a group -CON{sup,7 R-, CSNR{sup,7 -, SO{sub,2 NR{sup,7 -, CH{sub,2 O-, -CH=CH-; b) when B is a phenyl group, C can be a group -SO{sub,2 NR{sup,7 -, CH{sub,2 O-, -CH=CH-; D is a 5-tetrazolyl group or -COOR{sup,8 , R{sup,8 is hydrogen, (C{sub,1 -C{sub,4 )-alkyl or a phenylalkyl group; m and n are integers between 0 and 4. They have leukotriene antagonist action. They are used as anti-inflammatory, anti-allergic or for the treatment of cardiovascular diseases. |