abstract |
THE INVENTION REFERS TO COMPOUNDS OF THE FORMULA WHERE R SUB 1 AND R SUB 2 ARE INDEPENDENTLY HYDROGEN OR LOWER ALKYL OR SUB 1 YR SUB 2 TAKEN TOGETHER WITH THE CARBON ATOME TO WHICH THEY ARE UNITED FORM A 8-SPLIT CANDLE OF SPIRAL ; R SUB 3 AND R SUB 4 ARE INDEPENDENTLY HYDROGEN OR LOWER ALKYL OR R SUB 3 AND R SUB 4 TAKEN TOGETHER WITH THE CARBON ATOME TO WHICH THEY ARE UNITED, FORM A SPYRAL CONDENSED CYCLOALCAN OF 5 TO 8 CARBONS; R SUB 5 AND R SUB 6 TAKEN TOGETHER WITH THE NITROGEN ATOM TO WHICH THEY ARE UNITED ARE WHERE X EACH TIME IT APPEARS IT IS INDEPENDENTLY HYDROGEN, HALOGEN, LOWER ALKYL, NITRO, AMINO, CIAN, TRIFLUOROMETYL OR METOXY; Y M IS 0, 1 O 2; YOUR PHARMACEUTICALLY ACCEPTABLE ACID ADDITION SALTS AND WHERE YOUR OPTICAL AND GEOMETRIC ISOMERS AND RACEMIC BLENDS ARE APPLICABLE. THE COMPOUNDS OF THIS INVENTION ARE USEFUL AS ANALGESIC AND ANTI-HYPERTENSIVE AGENTS. |