abstract |
PRODRUGS OF 5,5-DIPHENYLHYDANTOIN. THE PRESENT INVENTION DEALS WITH A PRODUCT OF FORMULA (I), WHICH IS A NEW PRODRUG OF PHENYTOIN, AS WELL AS ITS SOLVATES AND THERAPEUTICALLY ACCEPTABLE ADDITION SALTS. THIS PRODUCT HAS SIGNIFICANTLY GREATER SOLUBILITY THAN PHENYTOIN ITSELF. FURTHERMORE, SURPRISINGLY, ITS RATE OF HYDROLYSIS IS MUCH HIGHER THAN THAT OF OTHER KNOWN PRODRUGS OF PHENYTOIN, WHICH MAKES IT POTENTIALLY USEFUL AS AN ANTIEPILEPTIC AND ANTIARRHYTHMIC AGENT. |