http://rdf.ncbi.nlm.nih.gov/pubchem/patent/ES-2068807-T3
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_382ccfc2ebebcaee15aa7cda4cee86bc |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D401-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D401-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-47 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D405-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D417-12 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-47 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D417-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D401-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D401-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D405-12 |
| filingDate | 1987-04-02-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 1995-05-01-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_4ea73445118c3ce762cae237cc11fa24 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_db011002def30cd5b6ece4dd45aeeb04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_ccd663a572506e23de47642055915c80 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_77c7a3af6291b298c810506faf879954 |
| publicationDate | 1995-05-01-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | ES-2068807-T3 |
| titleOfInvention | CARBOESTIRILE DERIVATIVES, PROCEDURE TO PREPARE THEM, PHARMACEUTICAL COMPOSITION, AND USE. |
| abstract | The use of a carbostyril derivative or a salt thereof represented by the general formula (1), ** formula ** where R is an unsaturated heterocyclic residual group selected from the groups 1,2,4 -triazolyl, imidazolyl, 1, 2,3,5-tetrazolyl, 1,2,3,4-tetrazolyl, pyrrolyl, benzimidazolyl, 1,3,4 -triazolyl, imidazolinyl, pyridyl, pyrimidinyl, pyrazolyl, pyrazolinyl, thiazolyl, thiazolinyl, 1,3,4 - oxadiazolyl, 1,3,4-thiadiazolyl, thienyl, furyl, pyranyl, isothiazolyl, isoxazolyl, pyrazinyl, pyridazinyl, indolyl, isoindolyl, 3H-indolyl, indolizinyl, indazolyl, quinolyl, isoquinolinylyl, chinolidinyl, chinylidinyl, choline, naphthyridinyl, chinyl, zinyl, zinyl, zinyl, zinyl, zinyl, zinyl, zinyl, zinyl, zinyl, zinyl, zinyl, zinyl, zinyl, zinyl, zinyl, zinyl. pyrrolinyl, pyrazolinyl, indolinyl and isoindolinyl, said unsaturated heterocyclic residual group can have from 1 to 3 substituents, heterocyclic residual over ring, selected from an oxo group; an uncle group; a group-phenyl; a group-phenyl that may have from 1 to 3 substituents, a defenyl ring, selected from a C1-C6 alkyl group, a C1-C6 haloalkyl group, a halogen atom, a hydroxy group, an amino group, an amino (C1-C6) alkyl group, a carboxy group and a C1-C6 alkoxy group; a C3-C8 cycloalkyl group; a phenylthio group; a C1-C6 alkyl group; a C1-C6 alkyl group having 1 to 2 substituents selected from an amino group, a (C1-C6) alkyl amino group and a carboxyl group; an amino group; a hydroxyl group; a cyano group; a carboxyl group; a (C1-C6) alkoxycarbonyl group; a C1-C6 phenylalkyl group which may have hydroxyl groups as substituents on the phenyl ring; a phenylsulfonyl group which may have C1-C6 alkyl groups as substituents on the phenyl ring; a C1-C6 phenylalkyl substituted with C1-C6 alkoxy; a (C1-C6) alkyl thio group; a C2-C6 alkenyl group; a C1-C6 alkoxy group and a pyridyl group; R1 is a hydrogen atom, a C1-C6 alkyl group, or a C1-C6 phenylalkyl group; R2 is a hydrogen atom, a halogen atom, a (C1-C6) alkyl sulfonyloxy group, a C1-C6 alkoxy group, or a hydroxyl group; Z is an oxygen atom, a sulfur atom, a group of the formula -C - !! Or, a group of formula -C - !! N -OH a group of formula -CH - !! OR3 (where R3 is a hydrogen atom or a C1-C6 alkyl group) or a group of the formula -NH-; A is a C2-C6 alkylene group; X is an oxygen atom, a sulfur atom, a group of the formula - SO - or a group of the formula - SO2 -; n is 0 or 1; and the carbon-carbon bond between positions 3 and 4 of the carbostyril skeleton is a single or double bond in the preparation of a drug for the treatment and prevention of arteriosclerosis, ischemic heart disease, chronic arterial obstruction, nephritis acute or chronic and treatment during artificial dialysis and implantation of an artificial organ. |
| priorityDate | 1986-04-02-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
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Total number of triples: 45.