| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_9433d383d1922b3df0ca6c182c7d3925 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D207-08
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D207-16 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D207-16 |
| filingDate |
1991-09-20-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate |
1994-02-16-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_3ea4716eaaea7f5958fb09d9b7c2444c
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_16f2aacf0aa5fde1532667ab342f00f7
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_8122ff16ace7a997703174a2825a9f3b
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_16b8cfad17a6bd52a5e8658524cbfd1e
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_2c9f7f26ab4609a3a02faeeea538c26a
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_f7c3ebf5dcb40e342506490d159a3a33
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_aa59443eca46fb743783e7587acd9ed0
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_e6029f7b48e79ae5007266cab36a69e2
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_b615590080b36a98c9cb04614811a4eb |
| publicationDate |
1994-02-16-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
ES-2035798-B1 |
| titleOfInvention |
PROCEDURE FOR THE PREPARATION OF 1- (2S) -3-MERCAPTO-METHYL-1-OXOPROPIL) -L-PROLINE. |
| abstract |
PROCEDURE FOR THE PREPARATION OF 1 - [(2S) -3-MERCAPTO-METHYL-1-OXOPROPIL] -L-PROLINE. NEW PROCEDURE FOR THE PREPARATION OF 1 - [(2S) -3-MERCAPTO-2-METHYL-1-OXOPROPIL] -L-PROLIN (CAPTOPRILE) OF FORMULA (I), WHICH INCLUDES THE HYDROGENATION OF 1 - [(2S) - 2-METHYL-1-OXO-3-RHODANIDE-PROPIL] -L-PROLIN OF FORMULA (II) IN AN INERT ENVIRONMENT, IN THE PRESENCE OF A CATALYST AT A TEMPERATURE BETWEEN 50 AND 120 C AND UNDER A PRESSURE OF 105 TO 107 PA. THE FORMULA (II) COMPOUND INDICATED ABOVE IS NEW AND CAN BE PREPARED BY ACILLATING L-PROLINE WITH A RECICENT ACILANT REACTIVE OF (2S) -2-METHYL-3-RHODANIDOPRO-PIONIC OF FORMULA (III). THE PROCEDURE ACCORDING TO THE INVENTION MAKES IT POSSIBLE TO OBTAIN THE COMPOUND OF FORMULA (I) SIMPLY AND WITH GREAT PURITY AND GOOD PERFORMANCE IN GENERAL. USE, PHARMACS AGAINST HYPERTENSION. |
| priorityDate |
1990-09-21-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |