| abstract |
PROCEDURE TO PREPARE A PHARMACEUTICAL COMPOSITION OF BIOLOGICALLY ACTIVE HUMAN RELAXIN. PROCEDURE TO PREPARE A PHARMACEUTICAL COMPOSITION OF BIOLOGICALLY ACTIVE HUMAN RELAXIN. IT CONSISTS OF INCORPORATING TO A PHARMACEUTICALLY ACCEPTABLE EXCIPIENT, A QUANTITY OF BIOLOGICALLY ACTIVE HUMAN RELAXIN OF APPROXIMATELY 0.01% TO 2% BY WEIGHT, ADDING A BUFFER CAPABLE OF KEEPING THE PH OF THE COMPOSITION AT A VALUE OF ABOUT APPROXIMATELY 7 BEING THE AMOUNT OF SAID BUFFER APPROXIMATELY 0.001% TO 0.5% BY WEIGHT, OPTIONALLY ADD AN ISOTONICITY AND OSMOLALITY ADJUSTMENT AGENT, A STABILIZING AGENT AND AN ABSORPTION ENHANCING AGENT, AS WELL AS OTHER EVENTS INGREDIENTS GIVE THE RESULTING COMPOSITION AN APPROPRIATE LIQUID, LYOPHILIZED, FROZEN OR GELIFIED FORM OF ADMINISTRATION. THE INVENTION IS USEFUL TO MODULATE REPRODUCTIVE PHYSIOLOGY IN HUMANS AND OTHER MAMMALS, IMPROVING LABOR AND PREVENTING IT FROM PREMATURE. |