| abstract |
PROCEDURE FOR THE PREPARATION OF CEPHALOSPORIN SALTS AND INJECTABLE COMPOSITIONS. THE ADDITIONAL CRYSTALLINE SALTS OF SULFURIC, DI-NITRIC, MONO-CHLORHYDRIC, DI-CHLOROPHYDRIC AND DI- AND SESQUI-ORTHO-PHOSPHORIC ACIDS OF 7- (2-AMINOTIAZOL-4-IL) - (Z) -METOXIIMINOACETIDO (1-METHYL-1-PYRROLIDINY) METHYL 3-CEFEM-4-CARBOXYLATE ARE STABLE EVEN AT HIGH TEMPERATURES. THE CRYSTALLINE SALT OF ADDITION OF SULFURIC ACID IS PREPARED BY FORMING A MIXTURE OF (A) AT LEAST A MOLAR EQUIVALENT OF SULFURIC ACID WITH (B) A QUANTITY OF ZWITTERION SUFFICIENT FOR ITS CONCENTRATION IN THE MIXTURE TO BE MORE THAN 25 MG / ML, H CRYSTALLIZE, SEPARATING CRITALS, WASHING AND DRYING. MONOHIDROCHLORIDE, DIHYDROCHLORIDE AND ORTHOPHOSPHATE SALTS ARE PREPARED BY DISSOLVING THE ZWITTERION IN THE PROPER AMOUNT OF ACID, CRYSTALLIZING BY ADDITION OF ACETONE AND ASYLATING CRYSTALS. |