abstract |
A PROCEDURE FOR THE PREPARATION OF HISTAMINE H2 ANTAGONISTS, FROM FORMULA (IV) WHERE R1 IS LOWER ALKYL, R2 AND R3 ARE LOWER ALKYL OR R2 AND R3 TAKEN TOGETHER WITH THE NITROGEN TO WHICH THEY ARE LINKED, MAY BE PYRROLIDINE, MAY BE PYRROLIDINE PIPERIDINE, METHYLPIPERIDINE, HOMOPIPERIDINE, HEPTAMETHYLENIMINE OR OCTAMETHYLENIMINE. THE PROCEDURE INCLUDES REACTING A COMPOUND OF FORMULA (I) WHERE R IS -CHO, -CH, -CH, -CH2OH OR -CH2X, WITH A COMPOUND OF FORMULA (A) IN A SOLVENT AND IN THE PRESENCE OF FORMIC ACID. THE COMPOUNDS (IV) OF THE INVENTION ARE USEFUL FOR THE TREATMENT OF PEPTIC ULCERS AND OTHER PATHOLOGIES CAUSED BY GASTRIC ACIDITY. O O OY OY (EYE FORMULA) |