abstract |
PROCEDURE FOR THE PREPARATION OF DICHLOROANILINE DERIVATIVES OF FORMULA I, WHERE X IS A LINK, A C1-6 ALKYLENE, OR C2-6 ALKYLENE OR ALKYLYLENE; AND IT IS A LINK, C1-4 ALKYLENE, OR C2-4 ALKYLENE OR ALKYLENE, AS THE SUM OF ATOMS OF C IN X E AND IS NOT GREATER THAN 8; AR IS SUBSTITUTED PHENYLL AND R1 AND R2 ARE HO RENT C1-3 AS THE SUM OF ATOMS OF C IN R1 AND R2 IS NOT GREATER THAN 4. THEY CAN BE OBTAINED BY RENTING AN AMINE II WITH A SUITABLE RENTAL AGENT SELECTED BETWEEN III AND IV; BY REDUCING AN INTERMEDIATE VI; AND BY DEPROTECTION OF AN INTERMEDIATE VII. THE COMPOUNDS (I) ASI OBTAINED EXERCISE STIMULATING ACTION IN THE B2-ADRENORRECEPTORS AND MAY BE USED FOR THE TREATMENT OF DISEASES ASSOCIATED WITH THE REVERSIBLE OBSTRUCTION OF RESPIRATORY TRACT SUCH AS ASTHMA AND CHRONIC BRONCHITIS. |