| abstract |
A PROCEDURE FOR THE PREPARATION OF FORMULA CEPHALOSPIRINASE IS DESCRIBED, AS DESCRIBED IN THE DESCRIPTION, WHICH INCLUDES THE N-ACILATION OF A 7-AMINO-3-CHLORO-3-CEFEM-4-CARBOXYLIC DERIVATIVE, WITH AN AGENT POLISHING AND OPTIONAL DEPROTECTION OF THE PRESENT PROTECTIVE GROUPS. THE COMPOUNDS OBTAINED BY THIS PROCEDURE, IN GENERAL, ACIDS 7-B-HETEROCICLILACETILACETILAMINO AND 7B-HETEROCICLILTIOACETAMIDO-3-CHLORO-3-CEFEM-4-CARBOXILICOS AND ITS SALTS PROVIDE A SURPRISING BIODISPONIBLE ELEMENTS AND UTILITIES FOR UTILITIES. IN MAN AND IN ANIMALS AND IN FORMULATIONS FOR ORAL ADMINISTRATION. |