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filingDate 2020-09-10-04:00^^<http://www.w3.org/2001/XMLSchema#date>
inventor http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_1755a7d3b64cfa572a3257c57f44144d
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publicationDate 2022-12-21-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber EP-4104839-A1
titleOfInvention 17beta-estradiol and vitamin c molecular complex, preparation method therefor and application thereof
abstract The present disclosure discloses a 17β-estradiol/vitamin C molecular complex, and a preparation method and a use thereof. The molecular complex is obtained by compounding of 17β-estradiol and vitamin C in a molar ratio of 0.25:1, 0.5:1, 0.75:1, 1:1, 1:0.25, 1:0.5, or 1:0.75. The present disclosure also provides a preparation method of the 17β-estradiol/vitamin C molecular complex. The 17β-estradiol/vitamin C molecular complex can be distributed to a bone tissue in a bone-targeted manner, which not only significantly improves the anti-osteoporosis activity of 17β-estradiol but also effectively prevents the side effects of endometrial hyperplasia and thrombosis caused by treatment with 17β-estradiol and conjugated estrogens.
priorityDate 2020-02-12-04:00^^<http://www.w3.org/2001/XMLSchema#date>
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